Tokushima University · Faculty of Dentistry · 准教授

Research keywordstumor immunology・thymic epithelial cells・Aire・self tolerance・angiogenesis・immune surveillance・head and neck cancer

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• Essential role of IkappaB kinase alpha in thymic organogenesis required for the establishment of self-tolerance
• Mode of Tolerance Induction and Requirement for Aire Are Governed by the Cell Types That Express Self-Antigen and Those That Present Antigen
• The E3 ligase RNF32 controls the IκB kinase complex and NF-κB signaling in intestinal stem cells
• Paradoxical development of polymyositis-like autoimmunity through augmented expression of autoimmune regulator (AIRE)

• 根本的治療法確立のための遺伝性自己免疫疾患の病態解明
• 難治性皮膚疾患・乾癬の免疫病態解析
• Fusobacterium nucleatumの増殖・凝集に関わる口腔癌微小環境の解明
• AIREの機能解析による自己免疫病態の解明

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