Tokushima University · Faculty of Medicine, Department of Medicine (Department of Integrative Medical Informatics)

Research keywords光遺伝学・細胞間情報伝達・生体イメージング・癌、イメージング、細胞間相互作用

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• Live-Cell FRET Imaging Reveals a Role of Extracellular Signal-Regulated Kinase Activity Dynamics in Thymocyte Motility.
• Knockout of all ErbB-family genes delineates their roles in proliferation, survival, and migration.
• Dynamics of the Ras/ERK MAPK cascade as monitored by fluorescent probes.
• FRET-assisted photoactivation of flavoproteins for in vivo two-photon optogenetics.

• 血管透過性のダイナミクスを司る低分子量Gタンパク質Rap1の分子的基盤の解明
• 細胞膜崩壊性細胞死によるDAMPs放出のメカニズムの解明
• 生体内AMPK可視化による、恒常性維持機構におけるAMPK機能の解明
• マウス生体内イメージング技術と光遺伝学ツールを用いた腫瘍微小環境の解明

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