Tokushima University · Unclassified

Research keywordsthymic epithelial cells・medullary thymic epithelium・central tolerance・Aire-expressing cells・thymocyte migration・thymic dendritic cells・cortical thymic epithelium・regulatory T cell development・thymoproteasome biology

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• Rank signaling links the development of invariant γδ T cell progenitors and Aire(+) medullary epithelium.
• TCR Affinity for In Vivo Peptide-Induced Thymic Positive Selection Fine-Tunes TCR Responsiveness of Peripheral CD8+ T Cells.
• The development of T lymphocytes in fetal thymus organ culture.
• Fine-tuning of β-catenin in mouse thymic epithelial cells is required for postnatal T-cell development

• 胸腺髄質人工器官の構築による自己免疫疾患治療法開発への挑戦
• 胸腺上皮細胞亜集団の分岐メカニズム
• 獲得免疫システムを特徴づける胸腺微小環境の分子基盤
• マウス胸腺微小環境を構成するWntシグナル活性化細胞の動態と機能の解析

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