Tokushima University · Faculty of Medicine, Department of Medicine (Department of Sensory Information Medicine)

Research keywordsallergy pharmacology・histamine H1 receptor・histidine decarboxylase・PKC delta signaling・antihistamines・allergic rhinitis・Tephrosia purpurea・dexamethasone

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• Combination of leukotoriene receptor antagonist with antihistamine has an additive suppressive effect on the up-regulation of H1-receptor mRNA in the nasal mucosa of toluene 2,4-diisocyanate-sensitized rat
• A novel benzofuran, 4-methoxybenzofuran-5-carboxamide, from Tephrosia purpurea suppressed histamine H1 receptor gene expression through a protein kinase C-δ-dependent signaling pathway
• ボリコナゾールが著効した副鼻腔と中耳の侵襲性アスペルギルス症例
• Effect of glucocorticoid on upregulation of histamine H-1 receptor mRNA in nasal mucosa of rats sensitized by exposure to toluene diisocyanate

• 前庭代償の新しい評価法を用いた前庭代償の促進薬の開発：動物モデルを用いた研究
• 血中好酸球増多に相関するＩＬ−３３遺伝子発現亢進の天然物由来抑制薬の同定
• 鼻粘膜ヒスタミン遺伝子発現のsiRNAによる抑制:動物モデルを用いた研究
• 花粉症に対する鼻噴霧ステロイド薬の初期療法の効果と分子メカニズムの解明

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