Tokushima University · Faculty of Pharmaceutical Sciences · 教授

Research keywordsGタンパク質共役型受容体・プロスタノイド・細胞内情報伝達系

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• A novel indole compound, AWT-489, inhibits prostaglandin D-2-induced CD55 expression by acting on DP prostanoid receptors as an antagonist
• PGE(1) and E-3 show lower efficacies than E-2 to beta- catenin-mediated activity as biased ligands of EP4 prostanoid receptors
• TRPM8 has a key role in experimental colitis-induced visceral hyperalgesia in mice
• Resolvin E1 and Resolvin E2 suppress cyclooxygenase-2 expression through ubiquitin-proteasome-mediated degradation in human macrophage-like U937 cells

• プロスタノイドEP4受容体の恒常的活性による細胞増殖速度調整メカニズムの解明
• EP受容体サブタイプ発現量バランスの崩壊により不可逆化するがん悪性化機構の解明

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