Tokushima University · Faculty of Pharmaceutical Sciences · 教授

Research keywordsPurkinje cell abnormalities・BCAP signaling・T-cell receptor signaling・B-cell activation・endoplasmic reticulum stress・calumin・CLN6 pathomechanisms・interleukin-2 signaling・neuronal ceroid lipofuscinosis

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• Protective role of the endoplasmic reticulum protein mitsugumin23 against ultraviolet C-induced cell death.
• A Requirement for the p85 PI3K Adapter Protein BCAP in the Protection of Macrophages from Apoptosis Induced by Endoplasmic Reticulum Stress.
• Purification of glutathione S-transferase fusion proteins as a non-degraded form by using a protease-negative E. coli strain, AD202.
• Contribution of calumin to embryogenesis through participation in the endoplasmic reticulum-associated degradation activity.

• モデルB細胞を用いた細胞増殖・細胞死制御におけるPI3K活性化の分子機構
• B細胞アダプター分子BLNKに結合する新規蛋白質の機能解析
• アダプター分子BCAPによる発がん抑制機構の機序解明
• 小胞体膜分子CLN6の凝集抑止能を制御する分子メカニズムの解明

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