Tokushima University · Harvard Medical School · 特任助教

Research keywords栄養学・ストレス顆粒・統合的ストレス応答・慢性ストレス・小胞体ストレス

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• Sulforaphane induces lipophagy through the activation of AMPK-mTOR-ULK1 pathway signaling in adipocytes.
• All-trans retinoic acid induces lipophagy through the activation of the AMPK-Beclin1 signaling pathway and reduces Rubicon expression in adipocytes.
• Reduction of stearoyl-CoA desaturase (SCD) contributes muscle atrophy through the excess endoplasmic reticulum stress in chronic kidney disease.
• All-trans retinoic acid reduces the transcriptional regulation of intestinal sodium-dependent phosphate co-transporter gene (Npt2b).

• 栄養素の過不足により生じる小胞体ストレス応答異常の解明
• ストレス顆粒を標的とした新たな老化細胞除去戦略

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