Tokushima University · Faculty of Pharmaceutical Sciences · 特任助教

Research keywordsliposomal drug delivery・PEGylated liposomes・anti-PEG IgM・accelerated blood clearance・exosome delivery・mRNA lipid nanoparticles・B cell antigen loading・cancer immunotherapy・spleen-targeted vaccines・liver metastasis therapy

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• Protein-bound cisplatin could exhibit an efficient antitumor effect in vivo
• An in vitro nanocarrier-based B cell antigen loading system; tumor growth suppression via transfusion of the antigen-loaded B cells in vivo
• A Stealthiness Evaluation of Main Chain Carboxybetaine Polymer Modified into Liposome
• Pegfilgrastim (PEG-G-CSF) induces anti-PEG IgM in a dose dependent manner and causes the accelerated blood clearance (ABC) phenomenon upon repeated administration in mice

• 人工高分子PEGの皮膚塗布により惹起される抗PEG抗体誘導現象のメカニズム解明
• 膜タンパクに対する抗体を誘導するエキソソームの脾臓免疫技術の基盤構築と応用研究
• イオン液体を用いた中分子医薬品の革新的・非侵襲的吸収促進技術の開発
• 抗核酸抗体分泌B細胞特異的な免疫寛容の誘導と全身性エリテマトーデス治療への応用

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