Tokushima University · Faculty of Dentistry · 講師

Research keywordsmultiple myeloma・myeloma microenvironment・bone pain・acidic extracellular microenvironment・bone resorption・1q amplification・proteasome inhibitor resistance・Reveromycin A

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• Myeloma cell growth suppression by osteoblast-derived extracellular vesicles: the creation of a non-permissive niche for myeloma cells by bone-forming osteoblasts.
• Disruption of the Cx43/miR21 pathway leads to osteocyte apoptosis and increased osteoclastogenesis with aging.
• Cancer-nerve interplay in cancer progression and cancer-induced bone pain.
• Inflammatory Cytokine-Induced Muscle Atrophy and Weakness Can Be Ameliorated by an Inhibition of TGF-β-Activated Kinase-1

• リン酸カルシウム置換型機能性ベクトルマテリアルに対する細胞応答の検討
• 骨形成環境による腫瘍排他的ニッチの分子機序の解明：新たながん治療戦略の可能性
• 治療後に安全にはがせるダイレクトボンディング剤の開発
• 骨折治癒におけるTIMP3の機能的意義と、新規骨折治癒促進薬の創薬

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