Tokushima University · Graduate School of Sciences and Technology for Innovation · 准教授

Research keywordsCHO cells・IgG production・bispecific diabodies・antibody engineering・cell engineering

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• Build-up functionalization of anti-EGFR × anti-CD3 bispecific diabodies by integrating high-affinity mutants and functional molecular formats.
• Improved gene amplification by cell-cycle engineering combined with the Cre-loxP system in Chinese hamster ovary cells.
• Stability difference of each chromosome in Chinese Hamster Ovary cell line
• Rearranging the domain order of a diabody-based IgG-like bispecific antibody enhances its antitumor activity and improves its degradation resistance and pharmacokinetics.

• 難発現性バイオ医薬品の生産手法の開発に向けた基盤研究
• バイオ医薬品生産細胞における老化現象の解明と制御
• 認知症死後脳のハイブリッドオミクス解析による認知症発症起源と疾患構造動態の解明
• 工業用動物細胞を用いた統合バイオプロセスに関する基盤的研究

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