Institute of Science Tokyo · Graduate School of Medical and Dental Sciences

Research keywordsmedicinal chemistry・peptidomimetics・amyloid-beta aggregation inhibitors・HIV-1 capsid inhibitors・SARS-CoV-2 main protease inhibitors・HBV capsid inhibitors

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• Takuya Kobayakawa, Marisa Arioka, Kenichi Yamamoto, Kohei Tsuji, Hirokazu Tamamura. Diastereoselective synthesis of (Z)-fluoroalkene dipeptide isosteres utilizing chiral auxiliaries. Organic & Biomolecular Chemistry. 2025.04; 23 (18): 4333-4336. ( DOI )2025
• Takuya Kobayakawa, Kenichi Yamamoto, Aiichiro Fukutome, Marisa Arioka, Kohei Tsuji, Hirokazu Tamamura. Design and synthesis of a C2-symmetric cyclic decapeptide and its peptidomimetic as potential inhibitors against amyloid-beta aggregation. SYNLETT. 2025.04; 36 (17): 2948-2952. ( DOI )2025
• Takuya Kobayakawa, Masaru Yokoyama, Kohei Tsuji, Sayaka Boku, Masaki Kurakami, Masayuki Fujino, Takahiro Ishii, Yutaro Miura, Soshi Nishimura, Kouki Shinohara, Kenichi Yamamoto, Peter Bolah, Osamu Kotani, Tsutomu Murakami, Hironori Sato, Hirokazu Tamamura. Development of Small-Molecule Anti-HIV-1 Agents Targeting HIV-1 Capsid Proteins. Chemical and Pharmaceutical Bulletin. 2024.01; 72 (1): 41-47. ( PubMed , DOI )2024
• Kohei Tsuji, Takuya Kobayakawa, Takahiro Ishii, Nobuyo Higashi-Kuwata, Chika Azuma, Kouki Shinohara, Yutaro Miura, Kenichi Yamamoto, Soshi Nishimura, Shin-ichiro Hattori, Haydar Bulut, Hiroaki Mitsuya, Hirokazu Tamamura. Exploratory Studies of Effective Inhibitors against the SARS-CoV-2 Main Protease by Halogen Incorporation and Amide Bond Replacement. Chemical & pharmaceutical bulletin. 2023; 71 (12): 879-886. ( PubMed , DOI )2023

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