Institute of Science Tokyo · Faculty of Medicine

Research keywordspulmonary fibrosis・systemic sclerosis・fibrotic interstitial lung disease・rheumatoid arthritis・inflammatory myopathies・muscle fiber necroptosis・CD8 T cells・fibroblast activation・COVID-19 thrombosis

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• Sasaki T, Cao Y, Sowerby JM, Higashioka K, Marks KE, Elahee M, Kamiya M, Dellaripa PF, Ainsworth RI, Taylor KE, Bottini N, Wolters P, Kim EY, Boin F, Rao DA.. A CD57+ CD8 T cell subset links cytotoxic T cell cytotoxicity to fibrotic lung disease in systemic sclerosis The Journal of Clinical Investigation. 2026.02; ( DOI )2026
• Li F, Vigder N, Ziehr DR, Kamiya M, Nguyen HN, Ferreyra Faustino DE, Khalil AH, Lam HC, Steinhauser ML, Kim EY, Oldham WM. TGF-β coordinates alanine synthesis and import for myofibroblast differentiation in pulmonary fibrosis. JCI Insight. 2026.04; ( DOI )2026
• Saifi MA, Marguerie F, Kamiya M, Nguyen HN, Knipe RS, Kim EY, Ho IC. Regulation of basal and tumour necrosis factor α-induced fibroblast gene expression by peptidylarginine deiminase 2 The Journal of Physiology. 2026.03; ( DOI )2026
• Yoji Komiya, Takahiko Sugihara, Tatsuro Ishizaki, Naoki Kimura, Mari Kamiya, Fumio Hirano, Takumi Matsumoto, Hirokazu Sasaki, Tadashi Hosoya, Shigeto Tohma, Shinsuke Yasuda, Toshihiro Matsui. The impact of aging and glucocorticoid use on physical function of older rheumatoid arthritis in remission: analysis of a National Database of Rheumatic Disease in Japan. Clin Rheumatol. 2025.07; ( PubMed , DOI )2025

• 傷害筋が誘導する免疫応答や筋機能障害を起点とした炎症性筋疾患の病態解明
• 筋運動による炎症性筋疾患抑制機序の解明
• 筋運動が自己免疫性筋炎に与える影響
• 筋細胞死の制御を標的とした多発性筋炎の治療法開発

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