Institute of Science Tokyo · Institute for Advanced Studies

Research keywordsgamma delta T cells・IL-17-producing lymphocytes・anti-MDA5 dermatomyositis・IL-21 signaling・autoimmune pathogenesis・mRNA therapeutics

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• TAp63, a methotrexate target in CD4+ T cells, suppresses Foxp3 expression and exacerbates autoimmune arthritis2023
• Efficacy and safety of dose escalation of tofacitinib in refractory anti-MDA5 antibody-positive dermatomyositis.2023
• IL-21 is required for the maintenance and pathogenesis of murine Vγ4+ IL-17-producing γδT cells2023
• Visceral disseminated varicella zoster virus infection during non-intensive maintenance therapy in a patient with systemic lupus erythematosus.2023

• 生体材料を応用したDAMPs捕捉薬による自己免疫疾患の新規治療モダリティの創生2025
• 自己免疫疾患発症にかかわるγδT17細胞の分化増殖におけるIL-21の役割の解明2023

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