Institute of Science Tokyo · International Research Institute for Medical-Engineering Collaboration

Research keywordsalpha-synuclein propagation・brain lymphatic system・tandem CAG repeat instability・PQBP1-cGAS-STING pathway・tau-induced neuroinflammation・DNA damage repair・Alzheimer's disease・frontotemporal lobar degeneration

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• Kyota Fujita, Hidenori Homma, Meihua Jin, Yuki Yoshioka, Xiaocen Jin, Yuko Saito, Hikari Tanaka, Hitoshi Okazawa. Mutant α-synuclein propagates via the lymphatic system of the brain in the monomeric state. Cell Rep. 2023.08; 42 (8): 112962. ( PubMed , DOI )2023
• Xiaocen Jin, Hikari Tanaka, Meihua Jin, Kyota Fujita, Hidenori Homma, Maiko Inotsume, Huang Yong, Kenichi Umeda, Noriyuki Kodera, Toshio Ando, Hitoshi Okazawa. PQBP5/NOL10 maintains and anchors the nucleolus under physiological and osmotic stress conditions. Nat Commun. 2023.01; 14 (1): 9. ( PubMed , DOI )2023
• Tanaka H, Okazawa H. PQBP1: The Key to Intellectual Disability, Neurodegenerative Diseases, and Innate Immunity. Int J Mol Sci. 2022.06; 23 (11): 6227. ( PubMed , DOI )2022
• Shiwaku H, Katayama S, Kondo K, Nakano Y, Tanaka H, Yoshioka Y, Fujita K, Tamaki H, Takebayashi H, Terasaki O, Nagase Y, Nagase T, Kubota T, Ishikawa K, Okazawa H, Takahashi H. Autoantibodies against NCAM1 from patients with schizophrenia cause schizophrenia-related behavior and changes in synapses in mice. Cell Rep Med. 2022.04; 3 (4): 100597. ( PubMed , DOI )2022

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• AAAS EurekAlert! The Global Souce for Science News
• アルツハイマー病におけるRNA顆粒制御に関わる新規分子の解明

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