Institute of Science Tokyo · Institute for Advanced Studies · 教授

Research keywordsprotein design optimization・protein-ligand complex prediction・cryo-EM receptor structure・lipid-gated ion channel・DJ-1 reaction mechanism・compound-protein interaction prediction・binding site prediction・graph transformer network

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• Akiba, R; Moriwaki, Y; Ishitani, R; Yoshikawa, N. Multi-objective optimization for designing structurally similar proteins with dissimilar sequences SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS-METHODS. 2026.12; 6 (1): ( DOI )2026
• Structural basis of lipid-mediated gating in a two-pore domain potassium channel 2025.11; ( DOI )2025
• Sano, FK; Shimizume, K; Kobayashi, K; Awazu, T; Kawakami, K; Akasaka, H; Kobayashi, TA; Tanaka, T; Okamoto, HH; Hirano, H; Kusakizako, T; Shihoya, W; Kise, Y; Itoh, Y; Ishitani, R; Okada, Y; Sako, Y; Yanagawa, M; Inoue, A; Nureki, O. Insights into G-protein coupling preference from cryo-EM structures of Gq-bound PTH1R NATURE CHEMICAL BIOLOGY. 2025.12; 21 (12): 1906-1914. ( PubMed , DOI )2025
• Zhang Y, Ishitani R, Takemoto M, Tomita A. Generalizable compound protein interaction prediction with a model incorporating protein structure aware and compound property aware language model representations. Communications chemistry. 2025.12; 9 (1): 37. ( PubMed , DOI )2025

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