Institute of Science Tokyo · Graduate School of Medical and Dental Sciences

Research keywordsbiguanides・acute kidney injury・COVID-19 outcomes・mesangial cell fibrosis・Porphyromonas gingivalis・TGF-beta1/Smad signaling

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• Biguanides are associated with decreased early mortality and risk of acute kidney injury in hospitalised patients with COVID-19: a nationwide retrospective cohort study in Japan.2026
• Sugimoto M, Kikuchi H, Sohara E, Mizutani K, Limbutara K, Hirakawa A, Mori T, Susa K, Oya S, Suzuki T, Naito S, Iimori S, Rai T, Fushimi K, Uchida S. Biguanides are associated with decreased early mortality and risk of acute kidney injury in hospitalised patients with COVID-19: a nationwide retrospective cohort study in Japan. Clinical and experimental nephrology. 2026.01; 30 (1): 33-44. ( PubMed , DOI )2026
• Porphyromonas gingivalis-derived lipopolysaccharide promotes mesangial cell fibrosis via transforming growth factor-beta1/Smad signaling pathway in high glucose.2025
• Sakaniwa E, Mikami R, Mizutani K, Mima A, Kido D, Kominato H, Saito N, Hakariya M, Takemura S, Nakagawa K, Sugimoto M, Sugiyama A, Iwata T. Porphyromonas gingivalis-derived lipopolysaccharide promotes mesangial cell fibrosis via transforming growth factor-beta1/Smad signaling pathway in high glucose. Journal of dental sciences. 2025.04; 20 (2): 989-994. ( PubMed , DOI )2025

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