Institute of Science Tokyo · Graduate School of Medical and Dental Sciences

Research keywordsGPCR deorphanization・metabolome interactome・E3-substrate interactome・antimicrobial peptides・antibiotic discovery・deep learning in biomedicine

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• Tomoya Sakuma , Yuki Otani , Hideyuki Shimizu. Geometric-Evolutionary Deep Learning Decodes the Human GPCR-Metabolome Interactome and Enables Systematic De-Orphanization bioRxiv. 2026.02; ( DOI )2026
• Yuki Otani , Daisuke Koga , Yasunari Wakizaka , Hideyuki Shimizu. BaCNet: Deep Learning Accelerates Novel Antibiotic Discovery Against Resistant Pathogens 2025.03; ( DOI )2025
• Yuki Otani , Daisuke Koga , Yasunari Wakizaka , Hideyuki Shimizu. AMP-Atlas: Comprehensive Atlas of Antimicrobial Peptides to Combat Multidrug-resistant Bacteria 2025.04; ( DOI )2025
• Tomoya Sakuma , Yuki Otani , Hideyuki Shimizu. High-Resolution Mapping of the Human E3-Substrate Interactome using Ubicon Uncovers Network Architecture and Cancer Vulnerabilities bioRxiv. 2025.04; ( DOI )2025

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