Institute of Science Tokyo · International Research Institute for Medical-Engineering Collaboration

Research keywords関節軟骨・再生医療・半月板・変形性膝関節症・滑膜・細胞治療・細胞老化・組織工学

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• Effects of local anesthetics on yield and differentiation of synovial mesenchymal stem cells. 2026.01; 16 (1): 5557. ( PubMed , DOI )2026
• Autofluorescence and cell size-based sorting eliminates senescent cells in synovial mesenchymal stem cells from patients with osteoarthritis. 2026.03; 101 103497. ( PubMed , DOI )2026
• Ichiro Sekiya, Hisako Katano, Mitsuru Mizuno, Kentaro Endo, Asuka Asami, Michiko Kajiwara, Naoki Otomo, Hideyuki Koga, Jun Masumoto, Nobutake Ozeki. 3D-MRI analysis of cartilage thickness changes after PRP injection in medial knee osteoarthritis: A preliminary report. PLoS One. 2025.04; 20 (4): e0321067. ( PubMed , DOI )2025
• Takuya Takakuwa, Kentaro Endo, Nobutake Ozeki, Yusuke Nakagawa, Hideyuki Koga, Makoto Tomita, Ichiro Sekiya. Enhanced lubricin secretion by human synovial mesenchymal stem cells compared to adipose mesenchymal stem cells. Stem Cell Res Ther. 2025.11; ( PubMed , DOI )2025

• ラット半月板自然修復過程において細胞老化が果たす役割の解明
• 物理刺激で関節内脂肪細胞リプログラムを誘導できるか―革新的な関節再生戦略の創出―
• バイオ３Ｄプリンタを用いた犬軟骨組織の体外構築と移植による軟骨再生治療効果の検討
• 変形性関節症の構造改善薬シーズの探索を目指した滑膜間葉系幹細胞遊走モデルの開発

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