Institute of Science Tokyo · Graduate School of Medical and Dental Sciences · 助教

Research keywordsHIV-1 latency reversal・HIV-1 Vpr・HIV-1 Vif・APOBEC3G・BRD4 degraders・macrophage infectivity・shock-and-kill・small-molecule antivirals・LINE-1 restriction・mannose receptor 1

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• Kohei Tsuji, Xueyuan Huang, Maho Miyamoto, Sayaka Sukegawa, Hidetomo Yokoo, Hiroaki Takeuchi, Yosuke Demizu and Hirokazu Tamamura. Application of HIV-1 viral protein R-derived-peptides as new E3 ligase-binding components of BRD4 degraders RSC Chem. Biol. 2025.10; ( DOI )2025
• Rosa Mallorson, Eri Miyagi, Sandra Kao, Sayaka Sukegawa, Hideki Saito, Helena Fabryova, Luciana Morellatto Ruggieri, Sonia Mediouni, Susana T Valente, Klaus Strebel. Transcriptional regulation of the HIV-1 inhibitory factor human mannose receptor 1 by the myeloid-specific transcription factor PU.1. Journal of virology. 2024.01; ( DOI )2024
• Kitamura H, Sukegawa S, Matsuda K, Tanimoto K, Kobayakawa T, Takahashi K, Tamamura H, Tsuchiya K, Gatanaga H, Maeda K, Takeuchi H.. 4-phenylquinoline-8-amine induces HIV-1 reactivation and apoptosis in latently HIV-1 infected cells Biochem Biophys Res Commun. 2023.01; ( DOI )2023
• Fabryova H, Kao S, Sukegawa S, Miyagi E, Taylor L, Ferhadian D, Saito H, Schaal H, Hillebrand F, Strebel K.. HIV-1 Vpr Induces Degradation of Gelsolin, a Myeloid Cell-Specific Host Factor That Reduces Viral Infectivity by Inhibiting the Expression and Packaging of the HIV-1 Env Glycoprotein. mBio. 2023.02; ( DOI )2023

• 新型コロナウイルスに対する性能評価試験の開発及び市場製品の調査
• 次世代解析技術によるHIV 潜伏機構解明およびウイルスリザーバ評価 系の開発研究
• マクロファージ細胞におけるHuman mannose receptor 1 (hMRC1) を介したHIV-1感染伝播制御に関わる宿主側要因の探索同定および その機構解明
• 新型コロナウイルスに対する製品の性能評価試験

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