Institute of Science Tokyo · Institute for Advanced Studies · 助教

Research keywordsエピジェネティクス・ケミカルバイオロジー・ヒストン修飾・構造生物学・情報学・計算機科学・Histone・Biochemistry

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• Hiroyuki J Kanaya, Ken Kuwajima, Yuko Ito, Yuta Shinohara, Yohei Okubo, Shinnosuke Shiono, Fumiya Tatsuki, Rei-Ichiro Ohno, Hideki Ukai, Maki Ukai-Tadenuma, Kenta Sumiyama, Hiroshi Fujishima, Rikuhiro G Yamada, Daisuke Tone, Hiroshi Kiyonari, Masaki Kikuchi, Takashi Umehara, Takashi Murayama, Kazunori Kanemaru, Masamitsu Iino, Koji L Ode, Takatsugu Hirokawa, Hiroki R Ueda. Isoflurane activates the type 1 ryanodine receptor to induce anesthesia in mice PLOS Biology. 2025.06; 23 (6):2025
• Sora Suzuki, Koji Umezawa, Gaku Furuie, Masaki Kikuchi, Daichi G.M. Nakamura, Nanae Fukahori, Ninako Kimura, Masato Yamakawa, Takashi Niwa, Takashi Umehara, Takamitsu Hosoya, Isao Kii. Temperature vaulting: A method for screening of slow- and tight-binding inhibitors that selectively target kinases in their non-native state 2025.10; 2952025
• Sae Matsuoka, Naoki Osada, Hirokazu Kubota, Ko Kikuzato, Hiroo Koyama, Takeshi Sonoda, Akiko Idei, Minoru Yoshida, Masaki Kikuchi, Takashi Umehara, Chiduru Watanabe, Teruki Honma, Hiroshi Yasui, Sho Ikeda, Naoto Takahashi, Hideki Nakasone, Jiro Kikuchi, Yusuke Furukawa. Discovery of a novel class NSD2 inhibitor for multiple myeloma with t(4;14)+ Blood Neoplasia. 2025.05; 2 (2):2025
• Yuki S Tateishi, Tamasa Araki, Satoru Kawai, Shuhei Koide, Yuko Umeki, Takashi Imai, Yumiko Saito-Nakano, Masaki Kikuchi, Atsushi Iwama, Hajime Hisaeda, Cevayir Coban, Takeshi Annoura. Histone H3.3 variant plays a critical role on zygote-to-oocyst development in malaria parasites. Parasitology International. 2024.01; ( PubMed , DOI )2024

• リシンアセチル化による後成遺伝情報の発現と継承の仕組みを理解する
• 治療と根治を両立する革新的マラリア制圧戦略の分子基盤に関する研究開発
• p300によるヌクレオソームアセチル化の構造基盤
• GAS41によるアセチル化ヌクレオソーム認識機構の解明

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