Institute of Science Tokyo · Institute for Advanced Studies · 准教授

Research keywordsCHCHD2・PPM1D/Wip1・オートファジー・ミトコンドリア・Ulk1・アポトーシス・リン酸化・黒質・キナーゼ・シグナル伝達

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• Tomoko Sakihara, Masatsune Tsujioka, Shinya Honda, Shigeomi Shimizu, Satoru Torii. Calcium and magnesium deficiency induces stress granule formation to maintain magnesium homeostasis. Cell structure and function. 2026; 51 (1): 55-65. ( PubMed , DOI )2026
• Kazuma Ohshima, Satoru Torii, Shigeomi Shimizu. Presence of Gut Microbiota Worsens D-Galactosamine and Lipopolysaccharide-Induced Hepatic Injury in Mice. Genes Cells. 2025.01; 30 (1): e13183. ( PubMed , DOI )2025
• Kohjin Suzuki, Naoki Watanabe, Satoru Torii, Satoko Arakawa, Kiyosumi Ochi, Shun Tsuchiya, Kazuhiro Yamada, Yoko Kawamura, Sadao Ota, Norio Komatsu, Shigeomi Shimizu, Miki Ando, Tomoiku Takaku. BCR::ABL1-induced mitochondrial morphological alterations as a potential clinical biomarker in chronic myeloid leukemia. Cancer Science. 2025.03; 116 (3): 673-689. ( PubMed , DOI )2025
• Yoichi Nibe-Shirakihara, Shinya Honda, Satoko Arakawa, Satoru Torii, Hajime Tajima Sakurai, Hirofumi Yamaguchi, Shigeru Oshima, Ryuichi Okamoto, Michael Lazarou, Hideshi Kawakami, Shigeomi Shimizu. Optineurin is an adaptor protein for ubiquitinated substrates in Golgi membrane-associated degradation. Nature Communications. 2025.10; 16 (1): 8966. ( PubMed , DOI )2025

• 低酸素応答に関わる細胞内情報伝達の細胞外環境依存的な制御機構の解析
• DNA傷害誘導性オートファジーを制御するPPM1D分子の役割
• 新規オートファジーを制御するUlk1のリン酸化解析とその生理的・病理的意義の解明
• Ｐａｒｋｉｎの新規基質ＩＰＡＳの解析によるパーキンソン病発症メカニズムの解明

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