Institute of Science Tokyo · Institute for Advanced Studies

Research keywordsclaudins・tight junctions・epithelial barrier・anti inflammatory peptides・protein crystallography・inhibitor peptides

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• Nakamura S, Tanimura Y, Nomura R, Suzuki H, Nishikawa K, Kamegawa A, Numoto N, Tanaka A, Kawabata S, Sakaguchi S, Emi A, Suzuki Y, Fujiyoshi Y. Structure-guided engineering of a mutation-tolerant inhibitor peptide against variable SARS-CoV-2 spikes. Proceedings of the National Academy of Sciences of the United States of America. 2025.01; 122 (4): e2413465122. ( PubMed , DOI )2025
• Oda Y, Takahashi C, Harada S, Nakamura S, Sun D, Kiso K, Urata Y, Miyachi H, Fujiyoshi Y, Honigmann A, Uchida S, Ishihama Y, Toyoshima F. Discovery of anti-inflammatory physiological peptides that promote tissue repair by reinforcing epithelial barrier formation. Science advances. 2021.11; 7 (47): eabj6895. ( PubMed , DOI )2021
• Shun Nakamura, Katsumasa Irie, Hiroo Tanaka, Kouki Nishikawa, Hiroshi Suzuki, Yasunori Saitoh, Atsushi Tamura, Sachiko Tsukita, Yoshinori Fujiyoshi. Morphologic determinant of tight junctions revealed by claudin-3 structures. Nat Commun. 2019.02; 10 (1): 816. ( PubMed , DOI )2019
• Shun Nakamura, Yoshinori Fujiyoshi, Katsumasa Irie. Enhancement of the thermostability of mouse claudin-3 on complex formation with the carboxyl-terminal region of Clostridium perfringens enterotoxin improves crystal quality. Acta Crystallogr F Struct Biol Commun. 2018.03; 74 (Pt 3): 150-155. ( PubMed , DOI )2018

• 構造生物学的アプローチによるタイトジャンクションの透過制御
• タイトジャンクション形成と透過制御の構造基盤解明
• 生体機能構築基盤としての上皮バリア学の新展開

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