Institute of Science Tokyo · Institute for Advanced Studies

Research keywordsendothelin signaling・TRPC channels・calcium entry・skeletal muscle cells・cancer stem cells・intestinal epithelium・chemotherapy resistance・cell reprogramming・STIM1 splice variant

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• Tsunaki Higa, Keiichi I Nakayama. Cell cycle heterogeneity and plasticity of colorectal cancer stem cells. Cancer Sci. 2024.05; 115 (5): 1370-1377. ( PubMed , DOI )2024
• Takeru Oka, Tsunaki Higa, Osamu Sugahara, Daisuke Koga, Shogo Nakayama, Keiichi I Nakayama. Ablation of p57+ Quiescent Cancer Stem Cells Suppresses Recurrence after Chemotherapy of Intestinal Tumors. Cancer Res. 2023.05; 83 (9): 1393-1409. ( PubMed , DOI )2023
• Tsunaki Higa, Yasutaka Okita, Akinobu Matsumoto, Shogo Nakayama, Takeru Oka, Osamu Sugahara, Daisuke Koga, Shoichiro Takeishi, Hirokazu Nakatsumi, Naoki Hosen, Sylvie Robine, Makoto M Taketo, Toshiro Sato, Keiichi I Nakayama. Spatiotemporal reprogramming of differentiated cells underlies regeneration and neoplasia in the intestinal epithelium. Nat Commun. 2022.03; 13 (1): 1500. ( PubMed , DOI )2022
• GPLD1+ cancer stem cells contribute to chemotherapy resistance and tumor relapse in intestinal cancer.

• 静止期維持因子p57を指標としたがん幹細胞の網羅的探索とがん根治治療モデルの確立
• 胸腺T細胞における正負の選択を決定する情報伝達回路の情報理論を用いた同定
• p57系統追跡と1細胞解析を用いた条件誘導型幹細胞の網羅的探索と脱分化機構の解明
• 胃底腺における神経－幹細胞間クロストークの解明と胃がんの新規治療戦略の開発

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