Institute of Science Tokyo · Graduate School of Medical and Dental Sciences · 助教

Research keywords口腔感染症学・自然免疫・病原細菌・感染症・口腔細菌

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• Hiroshi Ashida, Tokuju Okano, Tamako Iida, Poramed Onsoi, Chihiro Sasakawa, and Toshihiko Suzuki. Shigella type III secretion system effectors fine-tune host inflammation and cell death EMBO Journal. 2025.09;2025
• Tokuju Okano, Hiroshi Ashida, Masayuki Tsukasaki, Tamako Iida, Masahiro Yamamoto, Hiroshi Takayanagi, Takeharu Sakamoto, Toshihiko Suzuki. Hypoxia drives progression of multiple sclerosis by enhancing the inflammasome activation in macrophages with Porphyromonas gingivalis infection. Cell Death Discovery. 2025.06; 11 (1): 271. ( PubMed , DOI )2025
• Hiroshi Ashida, Tokuju Okano, Tamako Iida, Poramed Onsoi, Chihiro Sasakawa, Toshihiko Suzuki. Shigella type-III secretion system effectors counteract the induction of host inflammation and cell death. EMBO J. 2025.09; ( PubMed , DOI )2025
• Chen-Wei Hsu; Tokuju Okano; Yuiko Niinuma; Anongwee Leewananthawet; Tamako Iida; Poramed Onsoi; Kotchakorn Boonyaleka; Hiroshi Ashida; Toshihiko Suzuki. A complex of NLRP3 with caspase-4 is essential for inflammasome activation by Tannerella forsythia infection International Immunology. 2024.12; ( DOI )2024

• OSCE実施ワーキンググループ
• 口腔内細菌による自然免疫活性化が誘導する大腸癌増悪化機構の解明
• 歯周炎関連細菌誘導性インフラマソーム活性化によるリウマチ関節炎増悪化機構の解明
• 歯周炎関連細菌が引き起こす多発性硬化症増悪化メカニズムの解明

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