Institute of Science Tokyo · Institute for Advanced Studies

Research keywordsgrowth plate biomechanics・soft tissue growth・tissue atrophy・chondrocyte hypertrophy・stress anisotropy・long bone development

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• Chondrocyte hypertrophy in the growth plate promotes stress anisotropy affecting long bone development through chondrocyte column formation
• A thermal-mechanical coupling-inspired inelastic constitutive law for the growth and atrophy of biological soft tissues
• Development of continuum-based particle models of cell growth and proliferation for simulating tissue morphogenesis
• High-resolution image-based simulation reveals membrane strain concentration on osteocyte processes caused by tethering elements

• 骨形態形成メカニズム解明への力学的アプローチ
• 人工血管の導入による基底膜の凹凸構造を有する三次元培養皮膚モデルの構築

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