Institute of Science Tokyo · International Research Institute for Medical-Engineering Collaboration · 特任講師

Research keywords核酸医薬・遺伝子治療・神経科学・神経内科学

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• Katsuyama M, Matsubayashi T, Ying Y, Mon SSL, Kuroda T, Yoshida-Tanaka K, Hara RI, Yamada T, Ui-Tei K, Yoshioka K. Guanine base modifications in antisense oligonucleotides mitigate acute central nervous system toxicity. RSC chemical biology. 2026.03; ( PubMed , DOI )2026
• Kuroda T, Yoshioka K, Mon SSL, Katsuyama M, Sato K, Isogai E, Yoshida-Tanaka K, Iwata-Hara R, Yamaguchi T, Obika S, Yokota T. Unraveling and controlling late-onset neurotoxicity of antisense oligonucleotides through strategic chemical modifications. Molecular therapy. Nucleic acids. 2025.12; 36 (4): 102692. ( PubMed , DOI )2025
• Yoshimori M, Nishio M, Ohashi A, Maekawa Y, Shimomaki R, Kurata M, Yoshioka K, Yokota T, Nabeshima R, Arai A. Expression profiling of Epstein-Barr virus-derived microRNA in systemic chronic active EBV disease. International journal of hematology. 2025.12; 122 (6): 864-876. ( PubMed , DOI )2025
• Shimo T, Hasegawa J, Yoshioka K, Nakatsuji Y, Aso K, Tachibana K, Nagata T, Yokota T, Obika S. Effect of chemical modification on the exon-skipping activity of heteroduplex oligonucleotides. Molecular therapy. Nucleic acids. 2025.03; 36 (1): 102468. ( PubMed , DOI )2025

• アンチセンス核酸医薬の挑戦的脳デリバリー技術の創生
• Harnessing partial reprogramming to uncover rejuvenation strategies for aging brains
• 中枢神経を標的とした核酸医薬の高い有効性と安全性を有する技術開発に成功
• 「 中枢神経を標的とした核酸医薬の副作用の原因と改善法を発見 」― アルツハイマー型認知症などの神経難病の治療法開発に貢献 ―

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