Institute of Science Tokyo · International Research Institute for Medical-Engineering Collaboration · 特任准教授

Research keywords核酸医薬・ビタミンE・ペプチド化学・核酸・核酸化学・糖質化学

Research fields核酸医薬、ペプチド医薬、糖質化学・生体化学

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• Ryo Iwase , Taro Ishiguro , Rintaro I. Hara , Tetsuya Nagata , Takanori Yokota. G-Quadruplex-Based Splice Switching as a Therapeutic Approach in Duchenne Muscular Dystrophy ACS Chemical Biology. 2025.03; ( DOI )2025
• Taiki Matsubayashi, Kotaro Yoshioka, Su Su Lei Mon, Maho Katsuyama, Chunyan Jia, Takao Yamaguchi, Rintaro Iwata Hara, Tetsuya Nagata, Osamu Nakagawa, Satoshi Obika, Takanori Yokota. Favorable efficacy and reduced acute neurotoxicity by antisense oligonucleotides with 2',4'-BNA/LNA with 9-(aminoethoxy)phenoxazine. Mol Ther Nucleic Acids. 2024.06; 35 (2): 102161. ( PubMed , DOI )2024
• Hidetaka Torigoe , Sumire Nakayama , Tomomi Shiraishi , Kazuki Sato , Rintaro Iwata Hara , Takeshi Wada. Development of cationic oligodiaminogalactoses specifically binding to duplex RNA, but not to duplex DNA Thermochimica Acta. 2024.08; 738 179789. ( DOI )2024
• Kazutaka Nishina, Kotaro Yoshioka, Takanori Yokota, Rintaro Iwata Hara. Comparison of interaction between antimiR and microRNA versus HDO-antimiR and microRNA by molecular dynamics simulation. Nucleosides Nucleotides Nucleic Acids. 2024.01; 1-16. ( PubMed , DOI )2024

• グリオーシス回避を可能とする2本鎖核酸医薬の開発
• 核酸ナノ構造を特異的に認識する新規オリゴ糖のデザインと合成
• トランスフェリン介在性中枢神経送達を利用した髄腔内投与型オーバーハングヘテロ２本鎖核酸の研究開発
• TDP-43タンパク質を標的とした筋萎縮性側索硬化症の核酸医薬開発

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