Institute of Science Tokyo · Institute for Advanced Studies · 教授

Research keywordsosteoimmunology・rheumatoid arthritis・bone destruction・RANKL regulation・JAK inhibitors・osteoclast differentiation・periodontitis bone loss・immune fibroblast interactions

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• The neutrophil-osteogenic cell axis promotes bone destruction in periodontitis. 2024.02; 16 (1): 18. ( PubMed , DOI )2024
• 小松 紀子. 関節リウマチの病態形成における免疫-間葉系-骨連関 臨床免疫・アレルギー科. 2024.06; 81 (6): 590-593. ( 医中誌 )2024
• Okano, T; Ashida, H; Komatsu, N; Tsukasaki, M; Iida, T; Iwasawa, M; Takahashi, Y; Takeuchi, Y; Iwata, T; Sasai, M; Yamamoto, M; Takayanagi, H; Suzuki, T. Caspase-11 mediated inflammasome activation in macrophages by systemic infection of A. actinomycetemcomitans exacerbates arthritis INTERNATIONAL JOURNAL OF ORAL SCIENCE. 2024.08; 16 (1): 54. ( PubMed , DOI )2024
• Nam Cong-Nhat Huynh, Rui Ling, Komagamine Masatsugu, Shi Tianshu, Tsukasaki Masayuki, Matsuda Kotaro, Okamoto Kazuo, Asano Tatsuo, Muro Ryunosuke, Pluemsakunthai Warunee, Kollias George, Kaneko Yuko, Takeuchi Tsutomu, Tanaka Sakae, Komatsu Noriko, Takayanagi Hiroshi. 自己免疫性関節炎の薬物標的としてのオンコスタチンM駆動マクロファージ-線維芽細胞回路(Oncostatin M-Driven macrophage-fibroblast circuits as a drug target in autoimmune arthritis) Inflammation and Regeneration. 2024.07; 44 s41232-024. ( 医中誌 )2024

• 制御性T細胞を用いた関節リウマチ治療法の開発
• 関節炎におけるT細胞分化可塑性の意義の解明と治療法の開発
• 骨・関節細胞のダイナミクスと免疫系の制御を包括した統合運動器学の確立
• 関節リウマチの骨破壊を抑制する革新的な治療法の開発

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