Institute of Science Tokyo · Institute for Advanced Studies · 教授

Research keywordsワクチン・薬物送達システム・遺伝子治療・高分子ミセル・メッセンジャーRNA医薬品

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• Kosuke Fukuchi, Yuko Nakashima, Naoko Abe, Seigo Kimura, Fumitaka Hashiya, Yuichi Shichino, Yiwei Liu, Ryoko Ogisu, Satomi Sugiyama, Daisuke Kawaguchi, Masahito Inagaki, Zheyu Meng, Shiryu Kajihara, Mizuki Tada, Satoshi Uchida, Ting-Ting Li, Ramkrishna Maity, Tairin Kawasaki, Yasuaki Kimura, Shintaro Iwasaki, Hiroshi Abe. Internal cap-initiated translation for efficient protein production from circular mRNA. Nat Biotechnol. 2025.07; ( PubMed , DOI )2025
• Anjaneyulu Dirisala, Satoshi Uchida, Kazuko Toh, Junjie Li, Xueying Liu, Panyue Wen, Shigeto Fukushima, Kazunori Kataoka. Structural stability and RNase resistance of mRNA Polyplex micelles for systemic delivery. J Control Release. 2025.08; 384 113935. ( PubMed , DOI )2025
• Yasuo Yanagi, Hinako Ichikawa, Le Bui Thao Nguyen, Akimasa Hayashi, Naoko Abe, Hiroshi Abe, Satoshi Uchida. mRNA vaccination mitigates pathological retinochoroidal neovascularization in animal models. Vaccine. 2025.08; 61 127451. ( PubMed , DOI )2025
• Atsushi Hashimoto, Yuma Kunitomo, Ittoku Kikuchi, Hiroki Yamada, Keiko Kobayashi, Kazuhiro Soshiroda, Hiromi Aman, Yasuaki Kimura, Junichiro Yamamoto, Yasuhisa Shiraishi, Satoshi Uchida, Hiroshi Abe, Hiroto Iwai. Characterization of nuclease stability and poly(A)-binding protein binding activity of chemically modified poly(A) tail for in vivo applications RSC Chem Biol. 2025.08; ( PubMed , DOI )2025

• 単鎖抗体mRNAネブライジングによる多剤耐性菌治療法の開拓
• 脳内に核酸医薬を送達する高分子ミセルの創製と脳神経系難病の標的治療への展開
• 精密設計ペプチドを用いた細胞外DNAのin situ PEG被覆による抗炎症治療
• 標的指向性mRNA送達に基づく生体内CAR T細胞作製によるがん免疫治療

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