Institute of Science Tokyo · Institute for Advanced Studies · 教授

Research keywordsepigenetic drug discovery・histone deacetylases・lysine demethylases・PROTACs・heterochromatin protein 1・chemical biology・cancer therapeutics・small-molecule inhibitors

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• Jiranan Chotitumnavee, Peeratchai Seemaung, Rapeewan Settacomkul, Ratchanon Sukprasert, Yukihiro Itoh, Takayoshi Suzuki, Sirada Srihirun, Christopher Power, Pornpun Vivithanaporn. Targeted Degradation of Histone Deacetylase 8 Using Proteolysis Targeting Chimeras Technology: A Promising Approach for Glioblastoma Treatment Drug Design, Development and Therapy. 2026.01; 20 1-21. ( DOI )2026
• Akari Tokuyama, Yasunobu Yamashita, Ryo Maeda, Toshiki Akiyama, Yuri Takada, Ryunosuke Yoshino, Hiroki Kato, Shengwang Yu, Yukihiro Itoh, Makoto Tachibana, Takayoshi Suzuki. Identification of a novel small-molecule inhibitor of heterochromatin protein 1. Bioorg Med Chem Lett. 2026.02; 131 130469. ( PubMed , DOI )2026
• Mukherjee, A; Yamashita, Y; Maeda, R; Akiyama, T; Endo, K; Takada, Y; Tsumoto, H; Moriyama, Y; Ito, A; Shirai, F; Tachibana, M; Itoh, Y; Suzuki, T. A Novel PROTAC G9a/GLP Degrader that Inhibits, Similar to G9a siRNA, the Migration of MCF-7 Breast-Cancer Cells without Affecting Proliferation JOURNAL OF MEDICINAL CHEMISTRY. 2025.09; 68 (17): 18258-18271. ( PubMed , DOI )2025
• Yasunobu Yamashita, Yuuki Taki, Yoshinori Wakabayashi, Junichiro Kanazawa, Paddy R A Melsen, Yuri Takada, Yukihiro Itoh, Masanobu Uchiyama, Takayoshi Suzuki. A Deep-Learning-Aided Drug Screening Based on Visualization of a Hidden Layer as Chemical Space. ACS Med Chem Lett. 2025.07; 16 (7): 1299-1304. ( PubMed , DOI )2025

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