Institute of Science Tokyo · Graduate School of Medical and Dental Sciences · 助教

Research keywordsAllodynia・Anesthesia・Caチャネル・Cell・Endocrinology・Hyperalgesia・Internal・Molecular

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• Saegusa Hironao, Li Xu, Wang Xinshuang, Kayakiri Midori, Tanabe Tsutomu. Knockdown of microglial Cav2.2 N-type voltage-dependent Ca(2+)channel ameliorates behavioral deficits in a mouse model of Parkinson's disease FEBS LETTERS. 2020.06; 594 (17): 2914-2922. ( PubMed , DOI )2020
• Wang, X., Saegusa, H., Huntula, S. and Tanabe, T. . Blockade of microglial Cav1.2 Ca2+ channel exacerbates the symptoms in a Parkinson’s disease model. Scientific Reports . 2019.06; 9 (9138): 9138. ( PubMed , DOI )2019
• Huntula, S., Wang, X., Saegusa, H. and Tanabe, T.. Involvement of N-type Ca2+ channel in microglial activation and its implications to aging-induced exaggerated cytokine response. Cell Calcium. 2019.07; 82 102059. ( PubMed , DOI )2019
• Daisuke Kondo, Hironao Saegusa, Tsutomu Tanabe. Involvement of phosphatidylinositol-3 kinase/Akt/mammalian target of rapamycin/peroxisome proliferator-activated receptor γ pathway for induction and maintenance of neuropathic pain. Biochem. Biophys. Res. Commun.. 2018.05; 499 (2): 253-259. ( PubMed , DOI )2018

• 発作性失調症2型モデルマウスを用いた発症機構の解明と遺伝子治療の試み
• ミクログリアCaチャネルの神経変性疾患における役割
• ミクログリアCaチャネルの神経変性疾患における役割
• P/Q型CaチャネルをN型Caチャネルに置換したマウスの作製

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