Institute of Science Tokyo · Graduate School of Medical and Dental Sciences · 助教

Research keywordshepatocellular carcinoma・molecular classification・precision immune oncology・integrative transcriptomics・cancer stem cell properties・lipotoxicity resistance・lactate metabolism・ACVR2A signaling・acid ceramidase inhibition

This is a public-data preview. Personalized fit, contact angles, and saved workflows require sign-in.

• Atsushi Nara, Shu Shimada, Yoshimitsu Akiyama, Megumi Hatano, Yusuke Chino, Suguru Miyazawa, Hanako Tamura, Daisuke Asano, Yoshiya Ishikawa, Hiroki Ueda, Shuichi Watanabe, Eriko Katsuta, Keiichi Akahoshi, Kenichi Ohashi, Minoru Tanabe, Daisuke Ban, Shinji Tanaka. Targeting SPP1-CD44-Hedgehog Axis Elicits Therapeutic Effects in Hepatocellular Carcinoma by Suppressing Intratumoral Fibrosis. Cancer Sci. 2025.12; Online ahead of print. ( PubMed , DOI )2025
• Yasukawa K, Shimada S, Akiyama Y, Taniai T, Igarashi Y, Tsukihara S, Tanji Y, Umemura K, Kamachi A, Nara A, Yamane M, Akahoshi K, Shimizu A, Soejima Y, Tanabe M, Tanaka S. ACVR2A attenuation impacts lactate production and hyperglycolytic conditions attracting regulatory T cells in hepatocellular carcinoma. Cell Reports Medicine. 2024; in press. ( DOI )2024
• Igarashi Y, Akiyama Y, Shimada S, Watanabe S, Hatano M, Kodera K, Okazaki K, Tanji Y, Tsukihara S, Taniai T, Nara A, Yamane M, Kamachi A, Umemura K, Yasukawa K, Ono H, Akahoshi K, Tanabe M, Haruki K, Furukawa K, Ikegami T, Tanaka S. Identification and clinical implications of endogenous retrovirus elements suppressed by SETDB1 in hepatocellular carcinoma. JHEP Reports. 2024; in press. ( DOI )2024
• 蒲池厚志、秋山好光、島田周、波多野恵、田中真二. 胆道癌におけるエピゲノム異常とその臨床的意義 胆と膵. 2024.08; 45 (8): 835-843.2024

• 未分化型胃がんマウスモデルを利用した新規分子標的治療薬の開発2013
• 臨床検体の遺伝子発現情報を用いた仮想ダイセクション手法の開発とデータベース構築
• 円偏光散乱を用いたスキルス胃がん検出および早期がん進行度評価技術の確立
• ヒストン修飾異常に基づく難治性がんの腫瘍微小免疫環境変化と新規治療法の開発

• Official profile