Tokyo University of Pharmacy and Life Sciences · Department of Pharmacy / Faculty of Pharmaceutical Sciences · 助教

Research keywordsnonribosomal peptides・cyclic peptide synthesis・peptide cyclase・thioesterase domain・photoaffinity probes・sulfenylation chemistry・negamycin derivatives・readthrough activity・3CL protease

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• A Cysteine-Dependent Peptide Cyclase with Broad Substrate Tolerance Enables Chemoenzymatic Synthesis of Macolacin Analogs2026 · ACS Chemical Biology
• Evaluation of Readthrough Efficiency of Negamycin Derivatives against Nonsense Mutations in Muscular Dystrophy Genes2026 · Biological and Pharmaceutical Bulletin
• Tryptophan‐Selective Chemical Modification of Peptides by Thioether‐Mediated Sulfenylation2025 · ChemistryEurope
• Inhibition of Surfactin Biosynthesis in Bacillus Subtilis Using Cell‐Permeable Adenylation Domain Inhibitors2025 · ChemBioChem

• ペプチド環化酵素のリッド領域が担う環化制御機構の解明2026 · 科学研究費助成事業
• SARS-CoV-2 3CLプロテアーゼ阻害剤YH-53を基盤とする革新的創薬の展開2023 · 科学研究費助成事業
• ペプチド環化酵素の基質-酵素間相互作用解析に向けた遷移状態アナログの開発2023 · 科学研究費助成事業
• タンデム型ペプチド環化酵素の機能解析と化学酵素合成への応用2021 · 科学研究費助成事業 若手研究

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