Tokyo University of Pharmacy and Life Sciences · School of Life Sciences · 教授

Research keywordschromosome engineering・human artificial chromosomes・antibody engineering・transchromosomic mice・designer MSC・CRISPR antibody design・bowel targeting antibodies・inflammatory bowel disease

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• Targeting of bowel tissue by fully human antibodies cross-reactive with human and mouse GPA33 antigen.2025 · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
• Generation of transchromosomic mice harboring HLA-A/B/C and human B2M via mouse artificial chromosome and triple BAC integration.2025 · Scientific reports
• Rapid immunization and antibody redesign platform discovers broadly neutralizing antibodies against non-immunized SARS-CoV-2 variant.2025 · Molecular therapy : the journal of the American Society of Gene Therapy
• R-Spondin1 protects gastric stem cells and mitigates gastric GVHD in allogeneic hematopoietic stem cell transplantation.2024 · Blood advances

• 完全ヒト抗体産生ウサギ作製によるゲノム動作原理解明および高機能抗体取得の試み2025 · 科学研究費助成事業
• 抗LRP1抗体の超音波ナノバブル・イオン液体併用網膜薬物送達による緑内障治療戦略2025 · 科学研究費助成事業
• ゲノム編集誘導性分子多様化による、機能抗体・ペプチド表現型スクリーニングシステム2024 · 科学研究費助成事業
• ゲノム編集誘導性分子多様化による、機能抗体・ペプチド表現型スクリーニングシステム2023 · 科学研究費助成事業

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