Tottori University · Faculty of Medicine, Department of Medicine

Research keywordsoncolytic vaccinia virus・pancreatic ductal adenocarcinoma・tumor microenvironment・immune checkpoint blockade・IL-7 gene therapy・IL-12 gene therapy・Cdc42 signaling・viral neutralization escape

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• Long noncoding RNA UCA1 enhances sensitivity to oncolytic vaccinia virus by sponging miR-18a/miR-182 and modulating the Cdc42/filopodia axis in colorectal cancer
• lncRNA UCA1-Mediated Cdc42 Signaling Promotes Oncolytic Vaccinia Virus Cell-to-Cell Spread in Ovarian Cancer
• Fusogenic oncolytic vaccinia virus enhances systemic antitumor immune response by modulating the tumor microenvironment
• Anti-Tumor Effects of MAPK-Dependent Tumor-Selective Oncolytic Vaccinia Virus Armed with CD/UPRT against Pancreatic Ductal Adenocarcinoma in Mice

• 腫瘍溶解性ウイルスの細胞融合による腫瘍微小環境改善効果に立脚した新たな治療戦略
• 腫瘍溶解性ウイルスの細胞融合による腫瘍微小環境改善機序の解明とその応用

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