Toyama Prefectural University · Faculty of Engineering · 教授

Research keywordsUDP-glucuronosyltransferase・異物代謝・機能性食品・抱合化・ポリフェノール・Xnobiotics・UDP-グルクロン酸転移酵素・glucuronidation・functional food・ラット

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• 8-Prenylnaringenin tissue distribution and pharmacokinetics in mice and its binding to human serum albumin and cellular uptake in human embryonic kidney cells.
• Robust osteogenic efficacy of 2α-heteroarylalkyl vitamin D analogue AH-1 in VDR (R270L) hereditary vitamin D-dependent rickets model rats.
• Whole-cell dependent biosynthesis of N- and S-oxides using human flavin containing monooxygenases expressing budding yeast.
• Enhancing effect of the coexisting alpha-tocopherol on quercetin absorption and metabolism.

• ビタミンD水酸化酵素の立体構造に基づく機能改変と阻害剤の設計
• 3-メチルコラントレンにより誘導されるグルクロン酸転移酵素遺伝子の発現制御機構
• 薬物代謝酵素系(酸化酵素系と抱合酵素)を安定に発現する細胞株の開発
• 体内循環特性に基づくポリフェノール機能発現メカニズムの解明

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