Tokyo University of Agriculture and Technology · Graduate School of Engineering / Institute of Engineering · 准教授

Research keywordsG-quadruplex・telomestatin・chemical biology・ligand design・telomerase inhibition・click chemistry・PROTAC・atomic force microscopy

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• Loss of p53 Provokes NF-κB-Dependent Disruption of Nucleolar Cap and Nucleoplasmic Redistribution of Fibrillarin During Nucleolar Stress
• Visualization of G-quadruplexes by using a BODIPY-labeled macrocyclic heptaoxazole
• DESIGN AND SYNTHESIS OF TELOMESTATIN DERIVATIVES CONTAINING METHYL OXAZOLE AND THEIR G-QUADRUPLEX STABILIZING ACTIVITIES
• Targeting G-Quadruplex with Bis-thiourea Compounds Inhibits SARS-CoV-2 Replication

• 核酸立体構造を標的とした低分子創薬基盤技術の開発
• 歪みジイン化合物の特異的反応性を利用した生細胞接着技術への応用
• 非典型核酸高次構造を標的とした抗デングウイルス薬研究
• DNAの非典型的な立体構造を標的とした塩基書換え技術の開発

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