Tokyo University of Agriculture and Technology · Faculty of Agriculture · 准教授

Research keywordsメタロプロテアーゼ・変形性関節症・低密度リポタンパク質受容体関連タンパク質１・細胞外マトリックス・エンドサイトーシス

Research fieldsAnimal life science・Plastic surgery・Applied biochemistry・Functional biochemistry・Cell biology

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• JNK2 controls aggrecan degradation in murine articular cartilage and the development of experimental osteoarthritis
• A top-down approach to uncover the hidden ligandome of low-density lipoprotein receptor-related protein 1 in cartilage
• Post-translational regulation and proteolytic activity of the metalloproteinase ADAMTS8
• Arylsulfonamide inhibitors of aggrecanases as potential therapeutic agents for osteoarthritis: Synthesis and biological evaluation

• Optimising the functional potential of serpins to block cartilage breakdown: Implications for novel therapeutics for osteoarthritis
• Shedding of endocytic receptor LRP1 promotes osteoarthritis by altering extracellular trafficking of metalloproteinases
• 改変型TIMP-3を用いた選択的軟骨破壊阻害による進行性下顎頭吸収の抑制
• To delineate the role of endocytic receptor LRP1 in OA pathogenesis in vivo

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