Tokyo University of Agriculture and Technology · Graduate School of Engineering / Institute of Engineering · 教授

Research keywordsAptamer・CpG methylation detection・CpGメチル化検出・Evolutionary molecular engineering・バイオセンサ、アプタマー、進化分子工学、DNA/SNPセンサー・核酸工学・進化分子工学・バイオセンサ

Research fieldsAptamer・Biosensor・CpG methylation・バイオテクノロジー

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• Label free homogeneous detection of IgE by aptameric enzyme subunit
• Development of a mertansine-specific DNA aptamer and novel high-throughput sandwich enzyme-linked oligonucleotide assay for quantification and characterization of trastuzumab emtansine.
• Rapid and homogeneous electrochemical detection by fabricating a high affinity bispecific antibody-enzyme complex using two Catcher/Tag systems
• Pyrroloquinoline quinone (PQQ) prevents fibril formation of alpha-synuclein

• アプタマーセットを用いた血液中極微量疾病マーカーの多数同時検出法の開発
• DNAの構造安定性の変化を利用したCpGメチル化迅速検出法の開発
• 標的タンパク質に結合するアプタマー材料の探索
• 干渉増幅反射法を応用したバイオセンサーの開発

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