Tokyo University of Science · Faculty of Science Division I, Department of Applied Chemistry · 教授

Research keywords生物物理化学、構造生物学、遺伝子治療、癌、老化、ゲノム科学

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• Triplex formation involving 2 '-O,4 '-C-methylene bridged nucleic acid (2 ',4 '-BNA) with 2-pyridone base analogue: Efficient and selective recognition of C : G interruption
• Synergistic stabilization of nucleic acid assembly by oligo-N3 '-> P5 ' phosphoramidate modification and additions of comb-type cationic copolymers
• Triplex formation involving 2 '-O,4 '-C-methylene bridged nucleic acid (2 ',4 '-BNA) with 1-isoquinolone base analogue: Efficient and selective recognition of C : G interruption
• Positive cooperativity of the specific binding between Hg2+ ion and T:T mismatched base pairs in duplex DNA

• Telomere regulation mechanism by telomere binding proteins and telomerase
• テロメア結合蛋白質とテロメラーゼによるテロメア調節機構

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