Tokyo University of Science · Faculty of Pharmaceutical Sciences · 講師

Research keywordsバイオオルガノメタリクス・毒性学・環境健康学・血管毒性・重金属毒性

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• TGF-β1 potentiates the cytotoxicity of cadmium by induction of a metal transporter, ZIP8, mediated by the ALK5-Smad2/3 and ALK5-Smad3-p38 MAPK signal pathways in cultured vascular endothelial cells2022
• Synthesis of reactive sulfur species in cultured vascular endothelial cells after exposure to TGF-β1: induction of cystathionine γ-lyase and cystathionine β-synthase expression mediated by the ALK5-Smad2/3/4 and ALK5-Smad2/3-ATF4 pathways2021
• Expression profiles of purinergic P1 and P2 receptors in cultured bovine aortic endothelial cells, bovine aortic smooth muscle cells, and human vascular endothelial EA.hy926 cells
• Copper diethyldithiocarbamate as an activator of Nrf2 in cultured vascular endothelial cells

• 重金属に曝露された血管内皮細胞の擬似的メカニカルストレスとその毒性学的意義
• 草津温泉由来河川水および品木ダム浚渫土における重金属源流除去技術の構築と副次的資源活用可能性の評価に関する研究
• カドミウム毒性に対する血管内皮細胞の感受性を修飾する細胞外環境の変化
• PFASの血管機能障害の機序解明とその予防策

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