Tokyo University of Science · Faculty of Pharmaceutical Sciences · 助教

Research keywordsミトコンドリア

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• Glyoxalase 1 and protein kinase Cλ as potential therapeutic targets for late-stage breast cancer.
• Obesity-induced PARIS (ZNF746) accumulation in adipose progenitor cells leads to attenuated mitochondrial biogenesis and impaired adipogenesis.
• Correlation between c-Met and ALDH1 contributes to the survival and tumor-sphere formation of ALDH1 positive breast cancer stem cells and predicts poor clinical outcome in breast cancer
• High PKCλ expression is required for ALDH1-positive cancer stem cell function and indicates a poor clinical outcome in late-stage breast cancer patients

• 脂肪細胞のミトコンドリアストレスが惹起する全身性抗炎症反応
• ミトコンドリア生合成/分解の調節因子PARISを中心とした代謝病態機構の解明
• プリン塩基再利用経路を利用した乳がん細胞の生存戦略機構の解明

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