University of Shizuoka · Graduate School of Pharmaceutical Sciences / Faculty of Pharmaceutical Sciences · 准教授

Research keywords転写共役因子・転写因子・転写調節・脂質代謝・薬物代謝酵素・肝がん・核内受容体・PXR・CAR・ケム・バイオハイブリッド合成

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• Chemical characterization of anemia-inducing aniline-related substances and their application to the construction of a decision tree-based anemia prediction model.
• PXR stimulates growth factor-mediated hepatocyte proliferation by cross-talk with the FOXO transcription factor
• Phosphorylated Nuclear Receptor CAR Forms a Homodimer To Repress Its Constitutive Activity for Ligand Activation
• Identification of average molecular weight (AMW) as a useful chemical descriptor to discriminate liver injury-inducing drugs.

• 核内受容体PXRの上皮間葉転換抑制作用：肝がんに対する影響と機序の解明
• 核内受容体PXRによる肝細胞増殖制御：機序及びヒト影響の解明
• 非遺伝毒性肝発がん性の核内受容体活性化プロファイルに基づく評価の有用性検討
• 核内受容体PXRの上皮間葉転換抑制作用に基づく新規肝がん治療戦略

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