University of Shizuoka · Graduate School of Pharmaceutical Sciences / Faculty of Pharmaceutical Sciences · 助教

Research keywordscardiac arrhythmia・RyR2 inhibitors・cardiomyocyte assays・drug-induced QT・iPS cardiomyocytes・cardiac ion channels・sex hormone signaling・electrophysiology screening

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• Footprint analysis of recombination signal sequences in the 12/23 synaptic complex of V(D)J recombination.
• A novel RyR2-selective stabilizer prevents stress-induced ventricular arrhythmias without impairing cardiac function
• Overexpression of KCNJ2 in induced pluripotent stem cell-derived cardiomyocytes for the assessment of QT-prolonging drugs
• Cytoplasmic tethering is involved in synergistic inhibition of p53 by Mdmx and Mdm2.

• 薬物誘発性不整脈に関する機能解析および発症予測へ向けた統合的評価法の構築
• GCase受容体の構造生物学ーリガンドの認識機構と結合シグナルの分子内伝達機構
• 交感神経系刺激応答の性差に関わる心血管シグナル調節機構の網羅的解析
• 心筋カリウムチャネル複合体を介した心筋興奮終焉期の電気―Ca2＋同期機構の検証

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