University of Shizuoka · Graduate School of Pharmaceutical Sciences / Faculty of Pharmaceutical Sciences · 教授

Research keywordsSTAT3阻害剤・抗腫瘍性抗生物質・DNAアルキル化・IDO1阻害剤・SH2ドメインリガンド・プロテアソーム阻害剤・Eg5阻害剤・抗腫瘍免疫抑制

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• Identification and Characterization of a Novel Dual Inhibitor of Indoleamine 2,3-dioxygenase 1 and Tryptophan 2,3-dioxygenase
• Functional 1,3a,6a-triazapentalene scaffold: Design of fluorescent probes for kinesin spindle protein (KSP).
• Efficacy of combination treatment using YHO-1701, an orally active STAT3 inhibitor, with molecular-targeted agents on cancer cell lines.
• Visualization and quantification of dynamic STAT3 homodimerization in living cells using homoFluoppi.

• ＤＮＡアルキル化剤の新規作用機序に関する研究
• ファゴサイトーシス誘発作用に基づく制がん性PS二量等価体の創製
• in silico創薬技術を活用した転写因子阻害作用を有する新規抗がん剤の創製
• IDO/TDO二重阻害に基づく新規がん免疫治療薬の開発に向けた創薬基盤研究

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