University of Shizuoka · Graduate School of Pharmaceutical Sciences / Faculty of Pharmaceutical Sciences · 教授

Research keywordsがんの生物学・質量分析・糖鎖生物学・糖転移酵素・生化学・品質管理・フォールディング・Cancer Biology・EGF リピート・Notch シグナル

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• Notch受容体上のO-結合型糖鎖修飾の質量分析計を用いた網羅的解析
• O-Glycosylation modulates the stability of epidermal growth factor-like repeats and thereby regulates Notch trafficking
• O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation
• Protein O-glucosylation: another essential role of glucose in biology

• MUC1ムチンの機能と転写制御機構の解析
• Significance of novel specificity of Rumi in notch signaling
• 血管内皮におけるNotchシグナル精密制御の基盤となる非典型糖鎖修飾の統合的解析
• 腫瘍抑制因子 Notch1 がキシロース付加によって不活性化される分子機構の解析

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