The University of Tokyo · Graduate School of Agricultural and Life Sciences / Faculty of Agriculture · 教授

Research keywordsDNA methylation・epigenetic regulation・CpG islands・trophoblast stem cells・mouse embryogenesis・Nodal signaling・histone modification

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• Epidermal growth factor represses differentiation of mouse trophoblast stem cells into spongiotrophoblast cells via epidermal growth factor receptor
• Establishment of macaque trophoblast stem cell lines derived from cynomolgus monkey blastocysts.
• Enrichment of short interspersed transposable elements to embryonic stem cell-specific hypomethylated gene regions
• Phospholipase C-delta 1 and -delta 3 are essential in the trophoblast for placental development

• SRY遺伝子のアンチセンス遺伝子を用いた性分化の人為的制御に関する研究
• 性腺刺激ホルモンの生産システム:大腸菌とクローン動物の利用
• 生殖系列とクローン発生のゲノムDNAメチル化プログラム
• 胎盤の発生分化におけるNotch2シグナリングとその分子機構

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