The University of Tokyo · Graduate School of Frontier Sciences · 教授

Research keywords構造機能生物学・細胞内マグネシウム恒常性・終止コドン・翻訳終結・翻訳調節機構

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• Single molecule imaging of the trans-translation entry process via anchoring of the tagged ribosome
• Omnipotent decoding potential resides in eukaryotic translation termination factor eRF1 of variant-code organisms and is modulated by the interactions of amino acid sequences within domain 1
• A Single Amino Acid Substitution Alters Omnipotent eRF1 of Dileptus to Euplotes-type Dualpotent eRF1: Standard Codon Usage May be Advantageous in Raptorial Ciliates
• The mechanism of tryptophan induction of tryptophanase operon expression: Tryptophan inhibits release factor-mediated cleavage of TnaC-peptidyl-tRNA(Pro)

• tRNA擬態タンパク質によるリボソーム普遍機能と生体高次機能の発現機構解明
• 真核細胞リボソーム遺伝暗号解読における終結・再生過程の分子認識機序の解明
• 翻訳終結の調節機構
• 終止コドン多義性を実現するペプチド鎖解離因子のスイッチ制御機構の解明研究

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