The University of Tokyo · Institute of Medical Science

Research fieldsMolecular biology・Developmental biology

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• Proteasome-mediated degradation of Tob is pivotal for triggering UV-induced apoptosis.
• Coronin7 forms a novel E3 ubiquitin ligase complex to promote the degradation of the anti-proliferative protein Tob.
• Essential functions of the CNOT7/8 catalytic subunits of the CCR4-NOT complex in mRNA regulation and cell viability.
• Post-transcriptional Stabilization of Ucp1 mRNA Protects Mice from Diet-Induced Obesity.

• 細胞増殖抑制因子Tobの増殖・分化における役割とその発現制御機構の解析
• 細胞間相互作用を介した肝再生機構の解明と再生肝細胞の起源の同定
• 癌抑制遺伝子産物Tobによる細胞増殖制御機構と細胞の癌化・老化機構の解析
• 蛋白質リン酸化・脱リン酸化反応を介する細胞増殖と細胞癌化の制御

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