The University of Tokyo · Institute for Quantitative Biosciences · 特任助教

Research keywordsIL-1 signaling・dendritic cells・T cell regulation・Th17 cells・autoimmunity・collagen-induced arthritis

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• Analysis of the roles of IL-1 on homeostasis using mice deficient for negative regulators of IL-1 signaling
• Restriction of PD-1 function by cis-PD-L1/CD80 interactions is required for optimal T cell responses.
• PD-1 Primarily Targets TCR Signal in the Inhibition of Functional T Cell Activation.
• Robotic data acquisition with deep learning enables cell image-based prediction of transcriptomic phenotypes.

• 免疫抑制受容体PD-1による遺伝子発現制御システムの複合的オミクス解析
• Ｔ細胞活性化における転写開始点変化のメカニズムと生理的意義の解明
• 免疫抑制受容体の機能とエピジェネティクスの関係性の解明およびその制御
• PD-1により抑制されるT細胞の特性解明

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